《Imephu yeGlobal Diabetes》
Phantse i-10% yabantu abadala banesifo seswekile, kwaye isiqingatha sabo sihamba singafunyaniswanga.
Umntu omnye kwabayi-13 unonyamezelo lweglucose engaqhelekanga
Umntwana omnye kwabathandathu abasanda kuzalwa uchatshazelwa yi-hyperglycemia ngexesha lokukhulelwa
Umntu omnye uyafa rhoqo kwimizuzwana eyi-8 ngenxa yeswekile kunye neengxaki ...
--------International Diabetes Federatio
Ukuxhaphaka okuphezulu kwesifo seswekile kunye nokufa okuphezulu
Ngomhla we-14 kuNovemba luSuku lweSifo seswekile lweHlabathi.Kuqikelelwa ukuba i-463 yezigidi zabantu abaphakathi kweminyaka eyi-20 kunye ne-79 bahlala nesifo seswekile kwihlabathi jikelele, uninzi lwabo lunesifo seswekile se-2.Oku kulingana nomntu omdala omnye kwaba-11, ngokutsho kwe-IDF ye-Diabetes Atlas yamva nje, ushicilelo lwesithoba lwe-International Diabetes Federation.
Eyona nto yoyikisa ngakumbi kukuba i-50.1% yabantu abadala behlabathi abanesifo seswekile abazi ukuba banaso.Ngenxa yokungabikho kokufikelela kwiinkonzo zempilo, amazwe anengeniso ephantsi anelona nani liphezulu lezigulane ezingafunyaniswanga, kwi-66.8 yeepesenti, ngelixa amazwe anengeniso ephezulu aneepesenti ze-38.3 zezigulane ezingaxilwanga.
I-32% yabantu abanesifo seswekile kwihlabathi jikelele banesifo senhliziyo.Ngaphezulu kwe-80% yesifo sezintso zesigaba sokugqibela sibangelwa isifo sikashukela okanye uxinzelelo lwegazi okanye zombini.Unyawo lwesifo sikashukela kunye neengxaki zomlenze ophantsi zichaphazela i-40 kwi-60 yezigidi zabantu abanesifo sikashukela.Malunga ne-11.3% yokusweleka kwihlabathi jikelele inxulumene nesifo seswekile.Ngokumalunga ne-46.2% yokufa okunxulumene nesifo sikashukela phakathi kwabantu abangaphantsi kwe-60.
Uhlobo lwe-2 yeswekile kunye nesalathisi sobunzima bomzimba ophezulu kwandisa umngcipheko wee-cancer ezininzi eziqhelekileyo: kuquka isibindi, i-pancreatic, i-endometrial, i-colorectal kunye ne-cancer yamabele.Okwangoku, unyango oluqhelekileyo lwesifo seswekile lunyango lomntu ngamnye kunye neziyobisi, umthambo kunye nokutya okufanelekileyo, kwaye akukho nyango.
Intsangu yonyango 'ijolise' kwisifo seswekile
Uphononongo olutsha olupapashwe kwiJournal JAMA Internal Medicine lubonisa ukuba amayeza asekwe kwintsangu ayasebenza ekunciphiseni iimpawu kwiimpuku zesifo seswekile.Kuvavanyo, izehlo zeempuku zesifo seswekile ezisebenzisa i-cannabis zehla ukusuka kwi-86% ukuya kwi-30%, kwaye ukudumba kwe-pancreas kwathintelwa kwaye kwalibaziseka, kuthomalalisa iintlungu zemithambo-luvo.Kuvavanyo, iqela lifumene isiphumo esihle sentsangu yonyango kwisifo seswekile:
01
# Lawula imetabolism #
Ukucotha kwemetabolism kuthetha ukuba umzimba awukwazi ukwenza amandla ngokufanelekileyo, ukuphazamisa imisebenzi esisiseko, kubandakanywa nokulawulwa kweswekile yegazi, kwaye kukhokelela ekutyebeni.Amafutha amaninzi kakhulu emzimbeni anciphisa uvakalelo lweeseli zegazi kwi-insulin, nto leyo ephazamisa ukukwazi kwazo ukufunxa iswekile, ekwabizwa ngokuba kukunganyangeki kwe-insulin.Uphononongo lubonise ukuba abaguli abasebenzisa intsangu yonyango banokunganyangeki kwe-insulin ephantsi kunye nemetabolism ekhawulezayo, ekhuthaza "i-fat browning" kwaye inceda iiseli ezimhlophe zamafutha ziguquke zibe ziiseli ezimdaka.
i-metabolized kwaye isetyenziswe njengamandla ngexesha lomsebenzi womzimba ngaloo ndlela ikhuthaza imini yonke
intshukumo kunye nemetabolism yeeseli emzimbeni.
02
# Ukumelana ne-insulin esezantsi #
Xa iiseli zegazi zixhathisa kwi-insulin, ziyasilela ukukhuthaza ukuthuthwa kwe-glucose kwiiseli zeseli, ezikhokelela ekwakheni i-glucose.Intsangu yezonyango inamandla okuphucula amandla omzimba okufunxa nokusebenzisa i-insulin ngokufanelekileyo.Uphononongo luka-2013 olupapashwe kwi-American Journal of Medicine luhlalutye abantu abadala be-4,657, amadoda kunye nabasetyhini, kwaye bafumanisa ukuba izigulane ezihlala zisebenzisa i-marijuana yonyango zineepesenti ezili-16 zokunciphisa amanqanaba e-insulin yokuzila kunye ne-16 yepesenti yokunciphisa ukuxhatshazwa kwe-insulin.
03
# Yehlisa ukudumba kwe-pancreas #
Ukudumba okungapheliyo kweeseli ze-pancreas luphawu oluqhelekileyo lohlobo loku-1 lweswekile, xa amalungu omzimba evutha, akanakukhulula i-insulin.I-marijuana yonyango iyasebenza ekunciphiseni ukuvuvukala, ukunciphisa ukuvuvukala, kunye nokuxhaswa okuqhubekayo kunokunciphisa ubunzima bokuvuvukala kwi-pancreas kunye nokunceda ukulibazisa ukuqala kwesi sifo.
04
# Ukukhuthaza ukuhamba kwegazi #
I-hypertension engapheliyo yingxaki eqhelekileyo yohlobo lwe-1 kunye nohlobo lwe-2 yeswekile.Intsangu yonyango inokuvula imithambo yegazi, ikhuthaze ukuhamba kwegazi emithanjeni, ilawule ngcono uxinzelelo lwegazi, kwaye ithintele uxinzelelo lwegazi oluphezulu.
Kwi-2018, ingxelo ikhutshwe kwiNgqungquthela yeZibhayoloji ezahlukeneyo, echaza ngokucacileyo ukuba i-CBD yinto engokwemvelo kwaye ikhuselekile kwaye akukho nto inokwenzeka yokusetyenziswa kakubi.Kwanakwiidosi eziphakamileyo njenge-1,500 mg ngosuku, akukho miphumo emibi.Ke, ngaba intsangu yonyango ikhuselekile ukunyanga isifo seswekile?Ukudibana kweziyobisi okunokwenzeka kufuneka kuthathelwe ingqalelo apha.I-CBD inokufumana umlomo owomileyo kunye nokuguquguquka okuncinci kokutya xa usebenzisana namanye amayeza kagqirha, kodwa ezi zinqabile.
Leliphi ithamo elicetyiswayo le-CBD kwisifo seswekile?I-US Food and Drug Administration (FDA) ayikhange inike mpendulo icacileyo kulo mbuzo, kuba ukomelela komntu ngamnye ngokwasemzimbeni, ubunzima bomzimba, ubudala, isini, kunye nemetabolism zezinye zezinto ezininzi ezinempembelelo.Ke ngoko, ingcebiso eqhelekileyo yeyokuba izigulana ezinesifo seswekile ziqala ngokusetyenziswa kovavanyo lwedosi ephantsi kunye nohlengahlengiso lwedosi ngexesha.Uninzi lwabasebenzisi abayi kudlula i-25 milligrams yemihla ngemihla ye-CBD, kwaye phantsi kweemeko ezithile, i-dose efanelekileyo ye-100 mg ukuya kwi-400 mg.
I-CB2 i-agonist -caryophyllene BCP iyasebenza kuhlobo lwe-2 yeswekile
Abaphandi baseNdiya basanda kupapasha iphepha kwi-European Journal of Pharmacology ebonisa umphumo we-CB2 agonist -carbamene BCP kwi-2 yeswekile.Abaphandi bafumanisa ukuba i-BCP yenza ngokuthe ngqo i-receptor ye-CB2 kwiiseli ze-beta ezivelisa i-insulin kwi-pancreas, ekhokelela ekukhululweni kwe-insulin kunye nokulawula ukusebenza okuqhelekileyo kwe-pancreas.Kwangaxeshanye, ukusebenza kwe-BCP ye-CB2 kunempembelelo entle kwiingxaki zesifo seswekile, ezifana ne-nephropathy, i-retinopathy, i-cardiomyopathy kunye ne-neuropathy. luhlaza bumnyama, imifuno enamagqabi.)
# I-CBD yonyusa imveliso ye-insulin ngokuvula i-receptor yenkedama GPR55 #
Abaphandi baseBrazil abavela kwiYunivesithi yaseCalifornia, eMarin, bafunde iziphumo zezempilo ze-CBD kwimodeli yezilwanyana ze-diabetes ischemia.Abaphandi baye benza uhlobo lwe-2 yeswekile kwiimpuku zamadoda kwaye bafumanisa ukuba i-CBD inefuthe elihle kwisifo seswekile ngokunyusa i-insulin ye-plasma.
I-CBD inokuthoba iswekile yegazi kwiimpuku ezineemeko ezimandundu ngenxa yokunqongophala kweoksijini.Indlela yokusebenza icingelwa ukuba i-CBD inokunyusa imveliso ye-insulin ngokuvula i-receptor yentandane i-GPR55. Nangona kunjalo, ukukwazi kwe-CBD ukunciphisa umsebenzi we-CB1 (njengolawulo olubi lwe-allosteric) okanye ukukwazi ukwenza i-PPAR receptor inokuchaphazela i-insulin. khulula.
Intsangu yonyango inokusetyenziselwa ukunyanga umhlaza, ukucinezela ukuxhuzula, i-neurology, kunye nokuqaqanjelwa kwezihlunu, kunye nokulawula iintlungu.Oku kuya kuqhuba ukukhula, kunye nemarike yentsangu yehlabathi jikelele kulindeleke ukuba ifikelele kwi-148.35 yeebhiliyoni zeedola ngo-2026, ngokwezinyani zamva nje.《Iingxelo kunye neDatha》.
Ixesha lokuposa: Dec-04-2020